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KMID : 0525720080130010001
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Journal of Chitin and Chitosan
2008 Volume.13 No. 1 p.1 ~ p.5
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Antibacterial Activity Studies on a Low Molecular Water Soluble Chitosan
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Kim Mi-Hyun
Hahm Kyung-Soo
Jang Mi-Kyeong
Nah Jae-Woon
Park Seong-Cheol
Park Yoon-Kyung
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Abstract
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Four kinds of water-soluble chitosan were prepared for antibacterial activities. We studied the antibacterial activity and
mechanism of low molecular water-soluble chitosan in cells and vesicles of bacterial lipid compositions. Low molecular watersoluble chitosan displayed strong antibacterial activity against various pathogenic bacterial cells but showed no hemolytic activity in human red blood cells. In order to investigate the antibacterial mechanism(s) of low molecular water-soluble chitosan, calcein leakage was assessed on the basis of lipid composition (PE/PG; 7 : 3, w/w). Our result showing an interaction between low molecular water-soluble chitosan and liposomes demonstrated the chitosan-induced leakage from lipid vesicles. Finally, low molecular water-soluble chitosan causes significant morphological alterations in the bacterial surfaces as shown by scanning electron microscopy. Its potent antibacterial activity suggests that low molecular water-soluble chitosan is an excellent candidate as a lead compound for the development of novel anti-infective agents.
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KEYWORD
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Low molecular water-soluble chitosan, Antibacterial activity, Hemolytic activity, Scanning electron microscopy
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